Results of the Study conducted<\/a> had the following results:
\n(i) Here we show that clofazimine induces apoptosis in chronic myeloid leukaemia patient-derived blood mononuclear cells, with particularly robust effect in imatinib-resistant cells.
\n(ii) Clofazimine also induced apoptosis in CD34+38- progenitors and quiescent CD34+ cells from chronic myeloid leukaemia patients but not healthy donor-derived hematopoietic progenitors.
\n(iii) A mechanistic evaluation revealed that clofazimine via physical interaction with PPAR\u03b3 induced nuclear factor-kB-p65 proteasomal degradation, which led to sequential MYB and peroxiredoxin 1 downregulation and concomitant induction of reactive oxygen species-mediated apoptosis.
\n(iv) Clofazimine also suppressed STAT5 expression and consequently downregulated stem cell maintenance factors hypoxia-inducible factor -1\u03b1 and -2\u03b1 and Cbp\/P300 Interacting Transactivator with Glu\/Asp rich carboxy-terminal Domain 2.
\nCombining imatinib with clofazimine caused a far superior synergy than pioglitazone where clofazimine reduced imatinib’s IC50 by >4 logs and remarkably eroded quiescent CD34+ cells.<\/p>\nDr Naibedya says that the cost of launching a repurposed drug is 85% less than that incurred on launching a new drug, which means if proven in human clinical trials, the potential benefits are huge.
\nDelhi AIIMS doctors are also conducting a similar clinical trial on repurposed drugs. Recently, Dr Kameshwar Prasad, a professor of neurology at AIIMS, wrote to the Indian Council of Medical Research to set up a task force that will identify and validate low-cost alternatives to expensive drugs. He says that the doctors are already prescribing cheaper therapies. For example, a single cycle immune therapy for the treatment of Guillain-Barre-Syndrome (GBS), an acute inflammatory disorder of the peripheral nervous system, currently costs between Rs 3 lakh and Rs 8 lakh. To those who can\u2019t afford it, physicians are recommending steroids that cost less than Rs 5,000 and are equally effective.
\nDr Bhavana Kaul, one of the resident doctor of AIIMS has recently conducted a survey of physicians across India to assess the cheaper alternatives for GBS and the results were surprising. the results found that most physicians and neurologists were prescribing them since the standard treatment, in this case, immunoglobulin was not affordable. They also claimed that the response of patients was satisfactory.
\nBut, the new Indications for a drug need a huge investment to move from \u2018proof of concept\u2019 to the registered therapeutic use. Often, researchers lack funding to undertake clinical trials and pharmaceutical companies can be disinterested in repurposing generic drugs as it would fetch them little financial returns. India does not offer patent protection for new uses of known drugs, like in some western countries. Experts said that companies which hold a current patent for medicine could invest in the discovery of additional indications.<\/p>\n
Source: Times of India, Pressreader.com, Click Now.<\/p>\n","protected":false},"excerpt":{"rendered":"
The researchers at Central Drug Research Institute (CDRI) in Lucknow have recently found that certain leprosy drugs might help treat myeloma, a type of blood cancer. Clinical Researcher Sabyasachi Sanyal at CDRI in collaboration with clinical haematology department of King George\u2019s Medical University screened FDA-approved drugs in chronic myeloid leukaemia (CML) cells and found that […]<\/p>\n","protected":false},"author":12,"featured_media":5637,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[5],"tags":[232,662,406],"class_list":["post-5636","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-cancer","tag-indian-researchers","tag-leprosy"],"yoast_head":"\n
Leprosy drug to treat cancer? Researchers look for new uses of old drugs - DailyRounds<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.dailyrounds.org\/blog\/leprosy-drug-to-treat-cancer-researchers-look-for-new-uses-of-old-drugs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Leprosy drug to treat cancer? Researchers look for new uses of old drugs - DailyRounds\" \/>\n<meta property=\"og:description\" content=\"The researchers at Central Drug Research Institute (CDRI) in Lucknow have recently found that certain leprosy drugs might help treat myeloma, a type of blood cancer. Clinical Researcher Sabyasachi Sanyal at CDRI in collaboration with clinical haematology department of King George\u2019s Medical University screened FDA-approved drugs in chronic myeloid leukaemia (CML) cells and found that […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.dailyrounds.org\/blog\/leprosy-drug-to-treat-cancer-researchers-look-for-new-uses-of-old-drugs\/\" \/>\n<meta property=\"og:site_name\" content=\"DailyRounds\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-03T07:05:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.dailyrounds.org\/blog\/wp-content\/uploads\/2019\/09\/tab.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"852\" \/>\n\t<meta property=\"og:image:height\" content=\"480\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"DailyRounds\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"DailyRounds\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.dailyrounds.org\\\/blog\\\/leprosy-drug-to-treat-cancer-researchers-look-for-new-uses-of-old-drugs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.dailyrounds.org\\\/blog\\\/leprosy-drug-to-treat-cancer-researchers-look-for-new-uses-of-old-drugs\\\/\"},\"author\":{\"name\":\"DailyRounds\",\"@id\":\"https:\\\/\\\/www.dailyrounds.org\\\/blog\\\/#\\\/schema\\\/person\\\/f1f8f4904507b9ce4c90c65c9c06f454\"},\"headline\":\"Leprosy drug to treat cancer? 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The researchers at Central Drug Research Institute (CDRI) in Lucknow have recently found that certain leprosy drugs might help treat myeloma, a type of blood cancer. Clinical Researcher Sabyasachi Sanyal at CDRI in collaboration with clinical haematology department of King George\u2019s Medical University screened FDA-approved drugs in chronic myeloid leukaemia (CML) cells and found that an older leprosy drug called clofazimine, priced very low, was an inhibitor of these cells.