{"id":4378,"date":"2017-04-18T09:40:32","date_gmt":"2017-04-18T09:40:32","guid":{"rendered":"https:\/\/www.dailyrounds.org\/blog\/?p=4378"},"modified":"2017-04-18T09:40:32","modified_gmt":"2017-04-18T09:40:32","slug":"after-worlds-heaviest-woman-indian-doctors-to-treat-kids-with-similar-genetic-ailment","status":"publish","type":"post","link":"https:\/\/www.dailyrounds.org\/blog\/after-worlds-heaviest-woman-indian-doctors-to-treat-kids-with-similar-genetic-ailment\/","title":{"rendered":"After world\u2019s heaviest woman, Indian doctors to treat kids with similar genetic ailment"},"content":{"rendered":"

After helping the world\u2019s heaviest woman, Eman Ahmed from Egypt to cut down her weight of almost 500 kg by half in two months, Dr Muffazal Lakdawala plans to help three siblings-children who appear to have a genetic mutation like Eman, that\u2019s making them morbidly obese. The kids are from a Gujarat village.<\/p>\n

Yogita Nandwana, 7 years old, weighs 45 kg while 5 year old Anisha is heavier at 68 kg. Harsh, their three year old brother already weighs 25 kg. It\u2019s said that the three kids could together eat enough food in a week that would suffice for two families of four for a month. Since the kids\u2019 parents are poor, the rest of the village helps to feed the children.<\/p>\n

Gene mutation<\/strong><\/p>\n

As per Dr Lakdawala, a gene mutation, like in the case of Eman, is responsible for the severe obesity in the children.<\/p>\n

A genetic marker test conducted in Gujarat revealed the cause of the Nandwana siblings\u2019 obesity- mutation in the leptin receptor protein(LEPR) gene.<\/p>\n

At present, there exists no treatment for the condition. However, a drug-MC$R Agonist could help the kids. The drug is available only through a US pharma company. \u201cThe drug has been tested on three pediatric patients. We are trying to convince US officials to conduct the trial in India,\u201d said Dr Lakdawala to the Hindustan Times.<\/p>\n

The doctor added that the scheduled meeting with the officials of the US company is on April 20.<\/p>\n

\u201cThe village is so small we can\u2019t even get one kilogram of sugar at a time. There is not much work here but I work as a labourer and my wife works on a farm,\u201d said Ramesh, the children\u2019s father.<\/p>\n

The couple earns around Rs.5,000 a month- hardly enough for even the kids\u2019 food expenses-between Rs.6,000 and Rs.7,000 each month.<\/p>\n

\u201cThe entire village helps us to feed the children. Some give us rotis while others help out with gravy,\u201d said Ramesh.<\/p>\n

Every day, the kids consume over 30 rotis and over a kilo of vegetables. This is in addition to milk worth Rs 100. They also require wafers, biscuits and other snacks every half an hour so that they wouldn\u2019t become cranky.<\/p>\n

The family who is in Gujarat\u2019s Vajdi village is waiting for a response from the hospital, keeping their fingers crossed. Meanwhile, the kids\u2019 parents- Ramesh and Pradnya work tirelessly to make sure that the children don\u2019t go hungry.<\/p>\n

\u201cEarlier they would cry and howl if they didn\u2019t get food. But two years ago they were admitted to Ahmedabad civil hospital for 20 days. The food and the injections they received caused them to despise their hospital stay. Now they don\u2019t cry for food, fearing they will be sent back to the hospital, but they are still hungry all the time,\u201d Ramesh said.<\/p>\n

Earlier treatment<\/strong><\/p>\n

The first doctor to treat the children was Dr Akshay Mndviya of the Mandviya Children\u2019s Hospital in Gujarat. The doctor suspects that the kids have the genetic disorder, Prader-Willi syndrome(PWS)- a condition which affects multiple body parts and which causes obesity and Type-2 diabetes.<\/p>\n

\u201cWe really don\u2019t have the resources to diagnose the children but they used to come to us with other ailments such as pneumonia or fever. They could be treated if there was something wrong with their hormone levels but if it\u2019s a genetic problem, nothing much can be done,\u201d said Dr Mandviya.<\/p>\n

Once the local media reported the family\u2019s plight, the Ahmedabad Civil Hospital offered to treat the children.<\/p>\n

But as per Dr K M Maheria, head of paediatrics at Ahmedabad Civil Hospital, even they were unable to diagnose the problem. . \u201cWe don\u2019t have an endocrinologist but we did put the children on a diet. We saw a slight weight reduction but we couldn\u2019t provide any specific treatment,\u201d said Dr Maheria.<\/p>\n

It\u2019s said that the doctor has already spoken with Dr Lakdawala about the kids\u2019 condition.<\/p>\n

According to Ramesh, taking the kids to a hospital when nothing was medically wrong with them wasn\u2019t sensible. \u201cI thought it was better to focus on working and earning enough to feed them. They need a diet of fruit juices and salads but we can\u2019t afford it,\u201d he said.<\/p>\n

Image credits: hindustantimes.com<\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

After helping the world\u2019s heaviest woman, Eman Ahmed from Egypt to cut down her weight of almost 500 kg by half in two months, Dr Muffazal Lakdawala plans to help three siblings-children who appear to have a genetic mutation like Eman, that\u2019s making them morbidly obese. The kids are from a Gujarat village. Yogita Nandwana, […]<\/p>\n","protected":false},"author":11,"featured_media":4379,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[544,542,543],"class_list":["post-4378","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-genetic-ailment","tag-heaviest-woman","tag-kids"],"yoast_head":"\nAfter world\u2019s heaviest woman, Indian doctors to treat kids with similar genetic ailment - DailyRounds<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.dailyrounds.org\/blog\/after-worlds-heaviest-woman-indian-doctors-to-treat-kids-with-similar-genetic-ailment\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"After world\u2019s heaviest woman, Indian doctors to treat kids with similar genetic ailment - DailyRounds\" \/>\n<meta property=\"og:description\" content=\"After helping the world\u2019s heaviest woman, Eman Ahmed from Egypt to cut down her weight of almost 500 kg by half in two months, Dr Muffazal Lakdawala plans to help three siblings-children who appear to have a genetic mutation like Eman, that\u2019s making them morbidly obese. 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